Cytotoxic constituents of Psoralea corylifolia

Woongchon Mar; Kang Hun Je; Eun Kyoung Seo

doi:10.1007/BF02978259

Cytotoxic constituents of Psoralea corylifolia

Woongchon Mar, Kang Hun Je, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 microg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.

Original language	English
Pages (from-to)	211-213
Number of pages	3
Journal	Archives of Pharmacal Research
Volume	24
Issue number	3
DOIs	https://doi.org/10.1007/BF02978259
State	Published - Jun 2001

Bibliographical note

Funding Information:
This investigation was supported by a 2000 research grant from Ewha Womans University.

Access to Document

10.1007/BF02978259

Cite this

@article{c7e5bf0095e440e893fd2a2085f76702,

title = "Cytotoxic constituents of Psoralea corylifolia",

abstract = "A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 microg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.",

author = "Woongchon Mar and Je, {Kang Hun} and Seo, {Eun Kyoung}",

note = "Funding Information: This investigation was supported by a 2000 research grant from Ewha Womans University.",

year = "2001",

month = jun,

doi = "10.1007/BF02978259",

language = "English",

volume = "24",

pages = "211--213",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "3",

}

TY - JOUR

T1 - Cytotoxic constituents of Psoralea corylifolia

AU - Mar, Woongchon

AU - Je, Kang Hun

AU - Seo, Eun Kyoung

N1 - Funding Information: This investigation was supported by a 2000 research grant from Ewha Womans University.

PY - 2001/6

Y1 - 2001/6

N2 - A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 microg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.

AB - A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 microg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.

UR - http://www.scopus.com/inward/record.url?scp=0035377141&partnerID=8YFLogxK

U2 - 10.1007/BF02978259

DO - 10.1007/BF02978259

M3 - Article

C2 - 11440079

AN - SCOPUS:0035377141

SN - 0253-6269

VL - 24

SP - 211

EP - 213

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 3

ER -

Cytotoxic constituents of Psoralea corylifolia

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this