Cytotoxic constituents from the whole plant of Corydalis pallida

Rim Kim Hyang, Hye Young Min, Hee Jeong Yeon, Kook Lee Sang, Sook Lee Nam, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 μg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

Original languageEnglish
Pages (from-to)1224-1227
Number of pages4
JournalArchives of Pharmacal Research
Issue number11
StatePublished - Nov 2005

Bibliographical note

Funding Information:
This work was supported by a Korea Research Foundation Grant (KRF-2001-005-J01501 ).


  • Berberine
  • Corydalis pallida
  • Cytotoxicity
  • N-trans-Feruloylmethoxytyramine
  • N-trans-Feruloyltyramine
  • Papaveraceae


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