Cytotoxic constituents from the whole plant of Corydalis pallida

Rim Kim Hyang; Hye Young Min; Hee Jeong Yeon; Kook Lee Sang; Sook Lee Nam; Eun Kyoung Seo

doi:10.1007/bf02978202

Cytotoxic constituents from the whole plant of Corydalis pallida

Rim Kim Hyang, Hye Young Min, Hee Jeong Yeon, Kook Lee Sang, Sook Lee Nam, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC₅₀ values of 3.2 and 3.4 μg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

Original language	English
Pages (from-to)	1224-1227
Number of pages	4
Journal	Archives of Pharmacal Research
Volume	28
Issue number	11
DOIs	https://doi.org/10.1007/bf02978202
State	Published - Nov 2005

Bibliographical note

Funding Information:
This work was supported by a Korea Research Foundation Grant (KRF-2001-005-J01501 ).

Keywords

Berberine
Corydalis pallida
Cytotoxicity
N-trans-Feruloylmethoxytyramine
N-trans-Feruloyltyramine
Papaveraceae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/bf02978202

Cite this

@article{1a03b0fd862449f68218b10057924548,

title = "Cytotoxic constituents from the whole plant of Corydalis pallida",

abstract = "Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 μg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.",

keywords = "Berberine, Corydalis pallida, Cytotoxicity, N-trans-Feruloylmethoxytyramine, N-trans-Feruloyltyramine, Papaveraceae",

author = "Hyang, {Rim Kim} and Min, {Hye Young} and Yeon, {Hee Jeong} and Sang, {Kook Lee} and Nam, {Sook Lee} and Seo, {Eun Kyoung}",

note = "Funding Information: This work was supported by a Korea Research Foundation Grant (KRF-2001-005-J01501 ).",

year = "2005",

month = nov,

doi = "10.1007/bf02978202",

language = "English",

volume = "28",

pages = "1224--1227",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "11",

}

TY - JOUR

T1 - Cytotoxic constituents from the whole plant of Corydalis pallida

AU - Hyang, Rim Kim

AU - Min, Hye Young

AU - Yeon, Hee Jeong

AU - Sang, Kook Lee

AU - Nam, Sook Lee

AU - Seo, Eun Kyoung

N1 - Funding Information: This work was supported by a Korea Research Foundation Grant (KRF-2001-005-J01501 ).

PY - 2005/11

Y1 - 2005/11

N2 - Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 μg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

AB - Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with IC50 values of 3.2 and 3.4 μg/mL, respectively. N-trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

KW - Berberine

KW - Corydalis pallida

KW - Cytotoxicity

KW - N-trans-Feruloylmethoxytyramine

KW - N-trans-Feruloyltyramine

KW - Papaveraceae

UR - http://www.scopus.com/inward/record.url?scp=28844487452&partnerID=8YFLogxK

U2 - 10.1007/bf02978202

DO - 10.1007/bf02978202

M3 - Article

C2 - 16350845

AN - SCOPUS:28844487452

SN - 0253-6269

VL - 28

SP - 1224

EP - 1227

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 11

ER -

Cytotoxic constituents from the whole plant of Corydalis pallida

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this