Cytotoxic constituents from the roots of Tovomita brevistaminea

Eun Kyoung Seo; Monroe E. Wall; Mansukh C. Wani; Hernan Navarro; Rabindranath Mukherjee; Norman R. Farnsworth; A. Douglas Kinghorn

doi:10.1016/S0031-9422(99)00274-5

Cytotoxic constituents from the roots of Tovomita brevistaminea

Eun Kyoung Seo, Monroe E. Wall, Mansukh C. Wani, Hernan Navarro, Rabindranath Mukherjee, Norman R. Farnsworth, A. Douglas Kinghorn

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Two known xanthones, trapezifolixanthone and manglexanthone were isolated as cytotoxic constituents from the CHCl₃ extract of the roots of Tovomita brevistaminea by bioassay-guided fractionation using the KB cell line. In addition, a new compound, tovophenone C, and two known compounds, tovophenones A and B which are benzophenones, were found to be inactive constituents in this investigation. The structure of the new isolate was determined by detailed analysis of spectroscopic parameters including its 1D and 2D NMR spectroscopy data.

Original language	English
Pages (from-to)	669-674
Number of pages	6
Journal	Phytochemistry
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/S0031-9422(99)00274-5
State	Published - Oct 1999

Bibliographical note

Funding Information:
This investigation was supported by Grant U19-CA52956 from the National Cancer Institute, NIH, Bethesda, MD. We would like to thank Dr. J. Burgess for NMR experiments, and Ms. S. Spaulding and Ms. Y. Brackeen for technical assistance. Mr. R. B. Dvorak of the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, is acknowledged for the HREIMS data. R.M. thanks CNPq, Brazil, for financial assistance.

Keywords

Cytotoxic activity
Guttiferae
Prenylated benzophenones
Prenylated xanthones
Stems
Tovomita brevistaminea
Tovophenone C

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@article{059728960c5d4a22bcd8f4f864867e43,

title = "Cytotoxic constituents from the roots of Tovomita brevistaminea",

abstract = "Two known xanthones, trapezifolixanthone and manglexanthone were isolated as cytotoxic constituents from the CHCl3 extract of the roots of Tovomita brevistaminea by bioassay-guided fractionation using the KB cell line. In addition, a new compound, tovophenone C, and two known compounds, tovophenones A and B which are benzophenones, were found to be inactive constituents in this investigation. The structure of the new isolate was determined by detailed analysis of spectroscopic parameters including its 1D and 2D NMR spectroscopy data.",

keywords = "Cytotoxic activity, Guttiferae, Prenylated benzophenones, Prenylated xanthones, Stems, Tovomita brevistaminea, Tovophenone C",

author = "Seo, {Eun Kyoung} and Wall, {Monroe E.} and Wani, {Mansukh C.} and Hernan Navarro and Rabindranath Mukherjee and Farnsworth, {Norman R.} and Kinghorn, {A. Douglas}",

note = "Funding Information: This investigation was supported by Grant U19-CA52956 from the National Cancer Institute, NIH, Bethesda, MD. We would like to thank Dr. J. Burgess for NMR experiments, and Ms. S. Spaulding and Ms. Y. Brackeen for technical assistance. Mr. R. B. Dvorak of the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, is acknowledged for the HREIMS data. R.M. thanks CNPq, Brazil, for financial assistance.",

year = "1999",

month = oct,

doi = "10.1016/S0031-9422(99)00274-5",

language = "English",

volume = "52",

pages = "669--674",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

number = "4",

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T1 - Cytotoxic constituents from the roots of Tovomita brevistaminea

AU - Seo, Eun Kyoung

AU - Wall, Monroe E.

AU - Wani, Mansukh C.

AU - Navarro, Hernan

AU - Mukherjee, Rabindranath

AU - Farnsworth, Norman R.

AU - Kinghorn, A. Douglas

N1 - Funding Information: This investigation was supported by Grant U19-CA52956 from the National Cancer Institute, NIH, Bethesda, MD. We would like to thank Dr. J. Burgess for NMR experiments, and Ms. S. Spaulding and Ms. Y. Brackeen for technical assistance. Mr. R. B. Dvorak of the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, is acknowledged for the HREIMS data. R.M. thanks CNPq, Brazil, for financial assistance.

PY - 1999/10

Y1 - 1999/10

N2 - Two known xanthones, trapezifolixanthone and manglexanthone were isolated as cytotoxic constituents from the CHCl3 extract of the roots of Tovomita brevistaminea by bioassay-guided fractionation using the KB cell line. In addition, a new compound, tovophenone C, and two known compounds, tovophenones A and B which are benzophenones, were found to be inactive constituents in this investigation. The structure of the new isolate was determined by detailed analysis of spectroscopic parameters including its 1D and 2D NMR spectroscopy data.

AB - Two known xanthones, trapezifolixanthone and manglexanthone were isolated as cytotoxic constituents from the CHCl3 extract of the roots of Tovomita brevistaminea by bioassay-guided fractionation using the KB cell line. In addition, a new compound, tovophenone C, and two known compounds, tovophenones A and B which are benzophenones, were found to be inactive constituents in this investigation. The structure of the new isolate was determined by detailed analysis of spectroscopic parameters including its 1D and 2D NMR spectroscopy data.

KW - Cytotoxic activity

KW - Guttiferae

KW - Prenylated benzophenones

KW - Prenylated xanthones

KW - Stems

KW - Tovomita brevistaminea

KW - Tovophenone C

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U2 - 10.1016/S0031-9422(99)00274-5

DO - 10.1016/S0031-9422(99)00274-5

M3 - Article

C2 - 10570828

AN - SCOPUS:0033213182

SN - 0031-9422

VL - 52

SP - 669

EP - 674

JO - Phytochemistry

JF - Phytochemistry

IS - 4

ER -

Cytotoxic constituents from the roots of Tovomita brevistaminea

Abstract

Bibliographical note

Keywords

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