Cytotoxic constituents from the roots of Tovomita brevistaminea

Eun Kyoung Seo, Monroe E. Wall, Mansukh C. Wani, Hernan Navarro, Rabindranath Mukherjee, Norman R. Farnsworth, A. Douglas Kinghorn

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Two known xanthones, trapezifolixanthone and manglexanthone were isolated as cytotoxic constituents from the CHCl3 extract of the roots of Tovomita brevistaminea by bioassay-guided fractionation using the KB cell line. In addition, a new compound, tovophenone C, and two known compounds, tovophenones A and B which are benzophenones, were found to be inactive constituents in this investigation. The structure of the new isolate was determined by detailed analysis of spectroscopic parameters including its 1D and 2D NMR spectroscopy data.

Original languageEnglish
Pages (from-to)669-674
Number of pages6
Issue number4
StatePublished - Oct 1999

Bibliographical note

Funding Information:
This investigation was supported by Grant U19-CA52956 from the National Cancer Institute, NIH, Bethesda, MD. We would like to thank Dr. J. Burgess for NMR experiments, and Ms. S. Spaulding and Ms. Y. Brackeen for technical assistance. Mr. R. B. Dvorak of the Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, is acknowledged for the HREIMS data. R.M. thanks CNPq, Brazil, for financial assistance.


  • Cytotoxic activity
  • Guttiferae
  • Prenylated benzophenones
  • Prenylated xanthones
  • Stems
  • Tovomita brevistaminea
  • Tovophenone C


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