Cytotoxic constituents from the roots of Tovomita brevistaminea

Eun Kyoung Seo, Monroe E. Wall, Mansukh C. Wani, Hernan Navarro, Rabindranath Mukherjee, Norman R. Farnsworth, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Two known xanthones, trapezifolixanthone and manglexanthone were isolated as cytotoxic constituents from the CHCl3 extract of the roots of Tovomita brevistaminea by bioassay-guided fractionation using the KB cell line. In addition, a new compound, tovophenone C, and two known compounds, tovophenones A and B which are benzophenones, were found to be inactive constituents in this investigation. The structure of the new isolate was determined by detailed analysis of spectroscopic parameters including its 1D and 2D NMR spectroscopy data.

Original languageEnglish
Pages (from-to)669-674
Number of pages6
JournalPhytochemistry
Volume52
Issue number4
DOIs
StatePublished - Oct 1999

Keywords

  • Cytotoxic activity
  • Guttiferae
  • Prenylated benzophenones
  • Prenylated xanthones
  • Stems
  • Tovomita brevistaminea
  • Tovophenone C

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