Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

Bora Mun; Weihong Wang; Hiyoung Kim; Dongyup Hahn; Inho Yang; Dong Hwan Won; Eun Hee Kim; Jihye Lee; Chulkyeong Han; Hyunji Kim; Merrick Ekins; Sang Jip Nam; Hyukjae Choi; Heonjoong Kang

doi:10.1007/s12272-014-0480-8

Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

Bora Mun
, Weihong Wang
, Hiyoung Kim
, Dongyup Hahn
, Inho Yang
, Dong Hwan Won
, Eun Hee Kim
, Jihye Lee
, Chulkyeong Han
, Hyunji Kim
, Merrick Ekins
, Sang Jip Nam
, Hyukjae Choi
, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

Original language	English
Pages (from-to)	18-25
Number of pages	8
Journal	Archives of Pharmacal Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s12272-014-0480-8
State	Published - Jan 2015

Bibliographical note

Publisher Copyright:
© 2014 The Pharmaceutical Society of Korea.

Keywords

5α,8α-epidioxy sterol
Colorectal cancer
Cytotoxicity
Monanchora sp.
Pancreatic cancer
Renal cancer

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10.1007/s12272-014-0480-8

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@article{157b07ef72474431aa144c7db7bdb383,

title = "Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.",

abstract = "Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.",

keywords = "5α,8α-epidioxy sterol, Colorectal cancer, Cytotoxicity, Monanchora sp., Pancreatic cancer, Renal cancer",

author = "Bora Mun and Weihong Wang and Hiyoung Kim and Dongyup Hahn and Inho Yang and Won, \{Dong Hwan\} and Kim, \{Eun Hee\} and Jihye Lee and Chulkyeong Han and Hyunji Kim and Merrick Ekins and Nam, \{Sang Jip\} and Hyukjae Choi and Heonjoong Kang",

note = "Publisher Copyright: {\textcopyright} 2014 The Pharmaceutical Society of Korea.",

year = "2015",

month = jan,

doi = "10.1007/s12272-014-0480-8",

language = "English",

volume = "38",

pages = "18--25",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "1",

}

TY - JOUR

T1 - Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

AU - Mun, Bora

AU - Wang, Weihong

AU - Kim, Hiyoung

AU - Hahn, Dongyup

AU - Yang, Inho

AU - Won, Dong Hwan

AU - Kim, Eun Hee

AU - Lee, Jihye

AU - Han, Chulkyeong

AU - Kim, Hyunji

AU - Ekins, Merrick

AU - Nam, Sang Jip

AU - Choi, Hyukjae

AU - Kang, Heonjoong

PY - 2015/1

Y1 - 2015/1

N2 - Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

AB - Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

KW - 5α,8α-epidioxy sterol

KW - Colorectal cancer

KW - Cytotoxicity

KW - Monanchora sp.

KW - Pancreatic cancer

KW - Renal cancer

UR - https://www.scopus.com/pages/publications/84920553432

U2 - 10.1007/s12272-014-0480-8

DO - 10.1007/s12272-014-0480-8

M3 - Article

C2 - 25231340

AN - SCOPUS:84920553432

SN - 0253-6269

VL - 38

SP - 18

EP - 25

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 1

ER -

Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

Abstract

Bibliographical note

Keywords

UN SDGs

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