Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

Bora Mun; Weihong Wang; Hiyoung Kim; Dongyup Hahn; Inho Yang; Dong Hwan Won; Eun Hee Kim; Jihye Lee; Chulkyeong Han; Hyunji Kim; Merrick Ekins; Sang Jip Nam; Hyukjae Choi; Heonjoong Kang

doi:10.1007/s12272-014-0480-8

Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

Bora Mun, Weihong Wang, Hiyoung Kim, Dongyup Hahn, Inho Yang, Dong Hwan Won, Eun Hee Kim, Jihye Lee, Chulkyeong Han, Hyunji Kim, Merrick Ekins, Sang Jip Nam, Hyukjae Choi, Heonjoong Kang

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

Original language	English
Pages (from-to)	18-25
Number of pages	8
Journal	Archives of Pharmacal Research
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s12272-014-0480-8
State	Published - Jan 2015

Bibliographical note

Publisher Copyright:
© 2014 The Pharmaceutical Society of Korea.

Keywords

5α,8α-epidioxy sterol
Colorectal cancer
Cytotoxicity
Monanchora sp.
Pancreatic cancer
Renal cancer

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10.1007/s12272-014-0480-8

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title = "Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.",

abstract = "Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.",

keywords = "5α,8α-epidioxy sterol, Colorectal cancer, Cytotoxicity, Monanchora sp., Pancreatic cancer, Renal cancer",

author = "Bora Mun and Weihong Wang and Hiyoung Kim and Dongyup Hahn and Inho Yang and Won, {Dong Hwan} and Kim, {Eun Hee} and Jihye Lee and Chulkyeong Han and Hyunji Kim and Merrick Ekins and Nam, {Sang Jip} and Hyukjae Choi and Heonjoong Kang",

note = "Publisher Copyright: {\textcopyright} 2014 The Pharmaceutical Society of Korea.",

year = "2015",

month = jan,

doi = "10.1007/s12272-014-0480-8",

language = "English",

volume = "38",

pages = "18--25",

journal = "Archives of Pharmacal Research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "1",

}

TY - JOUR

T1 - Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

AU - Mun, Bora

AU - Wang, Weihong

AU - Kim, Hiyoung

AU - Hahn, Dongyup

AU - Yang, Inho

AU - Won, Dong Hwan

AU - Kim, Eun Hee

AU - Lee, Jihye

AU - Han, Chulkyeong

AU - Kim, Hyunji

AU - Ekins, Merrick

AU - Nam, Sang Jip

AU - Choi, Hyukjae

AU - Kang, Heonjoong

PY - 2015/1

Y1 - 2015/1

N2 - Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

AB - Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

KW - 5α,8α-epidioxy sterol

KW - Colorectal cancer

KW - Cytotoxicity

KW - Monanchora sp.

KW - Pancreatic cancer

KW - Renal cancer

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U2 - 10.1007/s12272-014-0480-8

DO - 10.1007/s12272-014-0480-8

M3 - Article

C2 - 25231340

AN - SCOPUS:84920553432

SN - 0253-6269

VL - 38

SP - 18

EP - 25

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 1

ER -

Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

Abstract

Bibliographical note

Keywords

UN SDGs

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