Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

Bora Mun, Weihong Wang, Hiyoung Kim, Dongyup Hahn, Inho Yang, Dong Hwan Won, Eun Hee Kim, Jihye Lee, Chulkyeong Han, Hyunji Kim, Merrick Ekins, Sang Jip Nam, Hyukjae Choi, Heonjoong Kang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalArchives of Pharmacal Research
Volume38
Issue number1
DOIs
StatePublished - Jan 2015

Keywords

  • 5α,8α-epidioxy sterol
  • Colorectal cancer
  • Cytotoxicity
  • Monanchora sp.
  • Pancreatic cancer
  • Renal cancer

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