Cytoprotective silica coating of individual mammalian cells through bioinspired silicification

Juno Lee, Jinsu Choi, Ji Hun Park, Mi Hee Kim, Daewha Hong, Hyeoncheol Cho, Sung Ho Yang, Insung S. Choi

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

The cytoprotective coating of physicochemically labile mammalian cells with a durable material has potential applications in cell-based sensors, cell therapy, and regenerative medicine, as well as providing a platform for fundamental single-cell studies in cell biology. In this work, HeLa cells in suspension were individually coated with silica in a cytocompatible fashion through bioinspired silicification. The silica coating greatly enhanced the resistance of the HeLa cells to enzymatic attack by trypsin and the toxic compound poly(allylamine hydrochloride), while suppressing cell division in a controlled fashion. This bioinspired cytocompatible strategy for single-cell coating was also applied to NIH 3T3 fibroblasts and Jurkat cells.

Original languageEnglish
Pages (from-to)8056-8059
Number of pages4
JournalAngewandte Chemie - International Edition
Volume53
Issue number31
DOIs
StatePublished - 28 Jul 2014

Keywords

  • bioinorganic chemistry
  • cell coating
  • cytoprotection
  • nanostructures
  • silica

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