Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1

Kyoung Ah Kang, Kyoung Hwa Lee, So Young Kim, Hee Sun Kim, Jin Sook Kim, Jin Won Hyun

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22 Scopus citations


The present study investigated the potential cytoprotective properties of a combination of plant extracts (KIOM-79) obtained from Magnolia officinalis, Pueraria lobata, Glycyrrhiza uralensis, and Euphorbia pekinensis, against the oxidative stresses induced by streptozotocin (STZ) in a rat pancreatic β-cells (RINm5F). KIOM-79 was found to scavenge intracellular reactive oxygen species (ROS), thereby preventing DNA damage and lipid peroxidation. The KIOM-79 inhibited apoptosis of the β-cells exposed to STZ via radical scavenging activity and activation of antioxidant enzymes. KIOM-79 inhibited activation of extracellular regulated kinase (ERK) induced by STZ and inhibited DNA binding activity of an activator protein-1 (AP-1), a downstream transcription factor of ERK. Taken together, these findings suggest that KIOM-79 protects against STZ induced cell death in RINm5F cells by inhibiting ROS generation and the ERK pathway.

Original languageEnglish
Pages (from-to)852-858
Number of pages7
JournalBiological and Pharmaceutical Bulletin
Issue number5
StatePublished - May 2007


  • Cytoprotective property
  • KIOM-79
  • Oxidative stress
  • Reactive oxygen species


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