Cytoprotective dihydronaphthalenones from the wood of Catalpa ovata

Yun Seo Kil, Yang Kang So, Min Jung Choi, Ah Reum Han, Chang Hyun Jin, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Three previously undescribed dihydronaphthalenones, 7-hydroxycatalponol, (4S)-3,4-dihydro-4-hydroxy-2-[(2R)-2,3-dihydroxy-3-methylbutylidene]naphthalen-1(2H)-one, and (6S)-5,6-dihydro-6-hydroxy-2,2-dimethyl-2H-benzo[h]chromen-4(3H)-one and one phthalide, (±)-3-(5-hydroxy-5-methyl-2-oxohex-3-en-1-yl)isobenzofuran-1(3H)-one, were isolated from the wood of Catalpa ovata G. Don (Bignoniaceae), together with six known compounds. The structures of the previously undescribed compounds were elucidated by interpretation of 1D and 2D NMR data. The absolute configurations of the dihydronaphthalenones were deduced by analysis of the ECD data and application of Mosher ester methodology. All isolates were investigated for their cytoprotective effects against hydrogen peroxide (H2O2)-induced oxidative damage in HepG2 cells. Moreover, the mRNA expression levels of antioxidant enzymes such as heme oxygenase-1 (HO-1) and NAD(P)H:quinine oxidoreductase 1 (NQO1) in HepG2 cells were examined by RT-PCR analysis. As a result, catalponol and epi-catalponol showed antioxidant activities via directly scavenging of intracellular ROS and inducing the antioxidant enzymes in vitro.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
StatePublished - Mar 2018

Bibliographical note

Funding Information:
This work was supported by Ewha Womans University .

Publisher Copyright:
© 2017


  • Bignoniaceae
  • Catalpa ovata
  • Cytoprotective effects
  • Dihydronaphthalenone
  • Heme oxygenase-1
  • NAD(P)H:quinine oxidoreductase 1
  • Phthalide
  • Reactive oxygen species


Dive into the research topics of 'Cytoprotective dihydronaphthalenones from the wood of Catalpa ovata'. Together they form a unique fingerprint.

Cite this