Cytomegalovirus infection in patients with new onset ulcerative colitis: A prospective study

You Sun Kim, Young Ho Kim, Joo Sung Kim, Jae Hee Cheon, Byong Duk Ye, Sung Ae Jung, Young Sook Park, Chang Hwan Choi, Byung Ik Jang, Dong Soo Han, Suk Kyun Yang, Won Ho Kim

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15 Scopus citations


Background/Aims: Immunosuppressive therapy in ulcerative colitis (UC) may induce cytomegalovirus (CMV) infection or reactivation in the colonic mucosa and in turn exacerbate UC. However, it is unclear whether colonic inflammation itself affects CMV infection in UC. This prospective study evaluated the prevalence and clinical outcome of CMV infection in patients with new onset UC who have not been exposed to UC medication. Methodology: A prospective, multi-center study was conducted in 65 patients with new onset UC. The presence of CMV was evaluated by a serology test and a histopathological examination including immunohistochemical staining. The assessment of clinical outcome was performed based on CMV positivity. Results: Evidence of CMV infection was found in three (4.5%) patients with UC. Two patients with moderate disease activity improved with 5-aminosalicylate or steroid treatment. One patient with severe active colitis, however, required antiviral therapy. Conclusions: CMV infection is rare in new onset UC, which suggests that use of immunosuppressive medications is an important risk factor for CMV infection in UC. However, CMV evaluation is necessary for severe active UC, even with new onset of the disease.

Original languageEnglish
Pages (from-to)1098-1101
Number of pages4
Issue number116
StatePublished - Jun 2012


  • Cytomegalovirus
  • Inflammation
  • Ulcerative colitis


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