Cytokine Delivery and Tissue Engineering

Seung Jin Lee

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Tissue engineering has been applied to various tissues, and particularly significant progress has been made in the areas of skin, cartilage, and bone regeneration. Inclusion of bioactive factors into the synthetic scaffolds has been suggested as one of the possible tissue engineering strategies. The growth factors are polypeptides that transmit signals to modulate cellular activities. They have short half-lives, for example, platelet-derived growth factor (PDGF), isolated from platelets, has a half life of less than 2 minutes when injected intravenously. Extended biological activity and the controlled release of growth factor are achieved by incorporating growth factor into the polymeric device. This review will focus on growth factor delivery for tissue engineering. Particular examples will be given whereby growth factors are delivered from a tissue-engineered device to facilitate wound healing and tissue repair.

Original languageEnglish
Pages (from-to)704-719
Number of pages16
JournalYonsei Medical Journal
Issue number6
StatePublished - Dec 2000


  • Cytokines
  • Peptide delivery
  • Vehicle


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