Cystic neoplasms of the exocrine pancreas: An update of a nationwide survey in Korea

Won Jae Yoon, Jun Kyu Lee, Kwang Hyuck Lee, Ji Kon Ryu, Yong Tae Kim, Yong Bum Yoon

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

OBJECTIVE:: The purpose of this study was to update a previous study of cystic neoplasms of the pancreas (PCNs) conducted in Korea by the authors. METHODS:: Clinicopathologic data and factors associated with malignancy were evaluated from PCNs originating from the exocrine pancreas diagnosed between January 1993 and June 2005 in 30 university hospitals throughout Korea. RESULTS:: A total of 1064 pathologically confirmed PCNs, which consisted of the following diagnoses, were collected: intraductal papillary mucinous neoplasm (IPMN), 436; mucinous cystic neoplasm (MCN), 268; solid pseudopapillary neoplasm (SPN), 195; serous cystic neoplasm (SCN), 162; acinar cell cystic neoplasm 2; and mature teratoma, 1. No malignant SCNs were diagnosed. In IPMN, advanced age, pancreatic head involvement, and hyperbilirubinemia were associated with malignancy based on multivariate analysis. In MCN, pancreatic head involvement was associated with malignancy based on multivariate analysis. CONCLUSIONS:: Intraductal papillary mucinous neoplasms were the most common PCN observed in Korea. Solid pseudopapillary neoplasms were observed more frequently than those in studies from western countries. In IPMNs, advanced age was associated with malignancy, suggesting an adenoma-carcinoma sequence. Involvement of the pancreatic head was associated with malignancy in both IPMNs and MCNs, possibly warranting prompt surgical interventions.

Original languageEnglish
Pages (from-to)254-258
Number of pages5
JournalPancreas
Volume37
Issue number3
DOIs
StatePublished - Oct 2008

Keywords

  • Cystic neoplasm of the pancreas
  • Intraductal papillary mucinous neoplasm
  • Mucinous cystic neoplasm
  • Serous cystic neoplasm
  • Solid pseudopapillary neoplasm

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