Cyclocurcumin from Curcuma longa selectively inhibits shear stress-induced platelet aggregation

T. Ngo, Keunyoung Kim, Yiying Bian, Gwang Jin An, Ok Nam Bae, Kyung Min Lim, Jin Ho Chung

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Curcuma longa (C. longa) has been the subject of intensive research for pleiotropic therapeutic potential. However, except for curcumin, the biological activities of other active ingredients of C. longa are not well known. Here, we demonstrated that C. longa extract significantly attenuated shear stress-induced platelet aggregation and cyclocurcumin exhibited the most potent activity (IC50 of 6.33 ± 3.29 μM). Cyclocurcumin potently inhibited shear stress-induced platelet activation, primarily through modulating the initial step, vWF – platelets GP Ib interaction. Moreover, cyclocurcumin effectively inhibited thrombus formation, without influencing platelet cell viability or blood clotting time. Collectively, we demonstrated that cyclocurcumin might be a promising therapeutic agent for the treatment or prevention of thrombotic diseases.

Original languageEnglish
Article number103462
JournalJournal of Functional Foods
Volume61
DOIs
StatePublished - Oct 2019

Keywords

  • Antiplatelet
  • Antithrombotic
  • Cardiovascular disease
  • Curcumin
  • Cyclocurcumin
  • SIPA

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