Cyclocurcumin, an antivasoconstrictive constituent of Curcuma longa (Turmeric)

Keunyoung Kim, Jung Jun Kim, Yeryeon Jung, Ji Yoon Noh, Ahmed Shah Syed, Chul Young Kim, Moo Yeol Lee, Kyung Min Lim, Ok Nam Bae, Jin Ho Chung

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50 against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in C. longa, may have a therapeutic potential as a novel antivasoconstrictive natural product. (Graph Presented).

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalJournal of Natural Products
Volume80
Issue number1
DOIs
StatePublished - 27 Jan 2017

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