Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation

Hyun Mi Kang; Ju Ryong Kim; Tae Sook Jeomg; Sung Gyu Choi; Young Han Ryu; Goo Taeg Oh; Nam In Baek; Byoung Mog Kwon

doi:10.1080/14786410500081494

Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation

Hyun Mi Kang, Ju Ryong Kim, Tae Sook Jeomg, Sung Gyu Choi, Young Han Ryu, Goo Taeg Oh, Nam In Baek, Byoung Mog Kwon

Department of Life Science

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC₅₀ values of 2.9 and 1.7μM, respectively, and they also inhibited cell-mediated LDL oxidation more than 5 times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor-deficient mice.

Original language	English
Pages (from-to)	37-41
Number of pages	5
Journal	Natural Product Research
Volume	20
Issue number	1
DOIs	https://doi.org/10.1080/14786410500081494
State	Published - Jan 2006

Bibliographical note

Funding Information:
This research was financially supported by a grant (code: PF0320506-0) from the Plant Diversity Research Center of 21st Century Frontier Research Program, a grant of Biogreen 21 Program of the Rural Development Administration, and the KRIBB Research Initiative Program.

Keywords

Alnus japonica
Diarylheptanoids
Low-density lipoprotein oxidation

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title = "Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation",

abstract = "Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7μM, respectively, and they also inhibited cell-mediated LDL oxidation more than 5 times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor-deficient mice.",

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note = "Funding Information: This research was financially supported by a grant (code: PF0320506-0) from the Plant Diversity Research Center of 21st Century Frontier Research Program, a grant of Biogreen 21 Program of the Rural Development Administration, and the KRIBB Research Initiative Program.",

year = "2006",

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doi = "10.1080/14786410500081494",

language = "English",

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AU - Kang, Hyun Mi

AU - Kim, Ju Ryong

AU - Jeomg, Tae Sook

AU - Choi, Sung Gyu

AU - Ryu, Young Han

AU - Oh, Goo Taeg

AU - Baek, Nam In

AU - Kwon, Byoung Mog

N1 - Funding Information: This research was financially supported by a grant (code: PF0320506-0) from the Plant Diversity Research Center of 21st Century Frontier Research Program, a grant of Biogreen 21 Program of the Rural Development Administration, and the KRIBB Research Initiative Program.

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N2 - Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7μM, respectively, and they also inhibited cell-mediated LDL oxidation more than 5 times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor-deficient mice.

AB - Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7μM, respectively, and they also inhibited cell-mediated LDL oxidation more than 5 times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor-deficient mice.

KW - Alnus japonica

KW - Diarylheptanoids

KW - Low-density lipoprotein oxidation

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Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation

Abstract

Bibliographical note

Keywords

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