Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation

Hyun Mi Kang, Ju Ryong Kim, Tae Sook Jeomg, Sung Gyu Choi, Young Han Ryu, Goo Taeg Oh, Nam In Baek, Byoung Mog Kwon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7μM, respectively, and they also inhibited cell-mediated LDL oxidation more than 5 times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor-deficient mice.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalNatural Product Research
Issue number1
StatePublished - Jan 2006


  • Alnus japonica
  • Diarylheptanoids
  • Low-density lipoprotein oxidation


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