Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation

Hyun Mi Kang, Ju Ryong Kim, Tae Sook Jeong, Sung Gyu Choi, Young Han Ryu, Goo Taeg Oh, Nam In Baek, Byoung Mog Kwon

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC 50 values of 2.9 and 1.7 μM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalNatural Product Research
Issue number2
StatePublished - Feb 2006

Bibliographical note

Funding Information:
This research was financially supported by a grant (code: PF0320506-0) from the Plant Diversity Research Center of 21st Century Frontier Research Program, a grant of Biogreen 21 Program of the Rural Development Administration, and the KRIBB Research Initiative Program.


  • Alnus japonica
  • Diarylheptanoids
  • Low-density lipoprotein oxidation


Dive into the research topics of 'Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation'. Together they form a unique fingerprint.

Cite this