Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia

Yong Pyo Lee, Sang Eun Yoon, Yuqin Song, Seok Jin Kim, Dok Hyun Yoon, Tsai Yun Chen, Young Il Koh, Ka Won Kang, Ho sup Lee, Kevin Tay Kuang Wei, Soon Thye Lim, Michelle Poon, Cosphiadi Irawan, Weili Zhao, Young Rok Do, Mark Hong Lee, Soo Chin Ng, Won Sik Lee, Ye Guo, Huilai ZhangHye Jin Kang, Hwan Jung Yun, Hyo Jung Kim, Daryl Tan Chen Lung, Jae Yong Kwak, Jae Joon Han, Yeung Chul Mun, Sung Yong Oh, Hyeok Shim, Jung Hye Kwon, Byeong Seok Sohn, Seong Kyu Park, Jae Cheol Jo, Young Hyeh Ko, Zhu Jun, Won Seog Kim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Cutaneous T-cell lymphomas (CTCLs) are a group of T-cell lymphomas with low incidence. Due to their indolent characteristics, treatment strategies have not yet been established for advanced CTCLs. In this study, relative incidence of CTCLs in Asia was estimated and the therapeutic outcomes presented based on various treatments currently used in clinics for advanced CTCLs. As part of a prospective registry study of peripheral T-cell lymphoma (PTCL) conducted across Asia, including Korea, China, Taiwan, Singapore, Malaysia, and Indonesia, subgroup analysis was performed for patients with CTCLs. Among 486 patients with PTCL, 37 with CTCL (7.6%) were identified between April 2016 and February 2019. Primary cutaneous ALK-negative anaplastic large cell lymphoma (ALCL, 35.1%) was the most common subtype. With a median follow-up period of 32.1 months, median progression-free survival (PFS) was 53.5 months (95% CI 0.0–122.5), and overall survival was not reached. 14 patients (48.2%) underwent subsequent treatment after the first relapse, but the response rate was 20% with a PFS of 2.2 months (95% CI 0.3–4.0). Six patients received autologous stem cell transplantation (auto-SCT). However, auto-SCT did not result in better outcomes. Additional studies are needed on standard care treatment of advanced or refractory and relapsed CTCLs.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalInternational Journal of Hematology
Issue number3
StatePublished - Sep 2021

Bibliographical note

Publisher Copyright:
© 2021, Japanese Society of Hematology.


  • Cutaneous
  • Incidence
  • Lymphoma
  • Prognosis
  • Survival
  • T-cell
  • Therapeutics


Dive into the research topics of 'Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia'. Together they form a unique fingerprint.

Cite this