Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; Association with pro-inflammatory cytokines

Chang Ki Min; Seok Lee; Yoo Jin Kim; Ki Seong Eom; Jong Wook Lee; Woo Sung Min; Chun Choo Kim; Chul Soo Cho; Gyeongsin Park

doi:10.1111/j.0902-4441.2005.t01-1-EJH2437.x

Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; Association with pro-inflammatory cytokines

Chang Ki Min, Seok Lee, Yoo Jin Kim, Ki Seong Eom, Jong Wook Lee, Woo Sung Min, Chun Choo Kim, Chul Soo Cho, Gyeongsin Park

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The proteasome inhibitor, bortezomib, has anti-myeloma activity even in myeloma cells refractory to multiple prior treatments. Bortezomib blocks the production of nuclear factor-κB (NFκB)-mediated pro-inflammatory cytokines. We report a patient with myeloma who developed a cutaneous leucoclastic vasculitis (LV) after bortezomib treatment. The patient with LV exhibited a marked increase in serum levels of IL-6, TNF-α, and C-reactive protein (CRP). Bortezomib administration may enhance the release of pro-inflammatory cytokines, which might play a role in bortezomib-induced cutaneous LV.

Original language	English
Pages (from-to)	265-268
Number of pages	4
Journal	European Journal of Haematology
Volume	76
Issue number	3
DOIs	https://doi.org/10.1111/j.0902-4441.2005.t01-1-EJH2437.x
State	Published - Mar 2006

Keywords

Bortezomib
IL-6
Leucolcastic vasculitis
Multiple myeloma
TNF-α

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10.1111/j.0902-4441.2005.t01-1-EJH2437.x

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title = "Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; Association with pro-inflammatory cytokines",

abstract = "The proteasome inhibitor, bortezomib, has anti-myeloma activity even in myeloma cells refractory to multiple prior treatments. Bortezomib blocks the production of nuclear factor-κB (NFκB)-mediated pro-inflammatory cytokines. We report a patient with myeloma who developed a cutaneous leucoclastic vasculitis (LV) after bortezomib treatment. The patient with LV exhibited a marked increase in serum levels of IL-6, TNF-α, and C-reactive protein (CRP). Bortezomib administration may enhance the release of pro-inflammatory cytokines, which might play a role in bortezomib-induced cutaneous LV.",

keywords = "Bortezomib, IL-6, Leucolcastic vasculitis, Multiple myeloma, TNF-α",

author = "Min, \{Chang Ki\} and Seok Lee and Kim, \{Yoo Jin\} and Eom, \{Ki Seong\} and Lee, \{Jong Wook\} and Min, \{Woo Sung\} and Kim, \{Chun Choo\} and Cho, \{Chul Soo\} and Gyeongsin Park",

year = "2006",

month = mar,

doi = "10.1111/j.0902-4441.2005.t01-1-EJH2437.x",

language = "English",

volume = "76",

pages = "265--268",

journal = "European Journal of Haematology",

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AU - Min, Chang Ki

AU - Lee, Seok

AU - Kim, Yoo Jin

AU - Eom, Ki Seong

AU - Lee, Jong Wook

AU - Min, Woo Sung

AU - Kim, Chun Choo

AU - Cho, Chul Soo

AU - Park, Gyeongsin

PY - 2006/3

Y1 - 2006/3

N2 - The proteasome inhibitor, bortezomib, has anti-myeloma activity even in myeloma cells refractory to multiple prior treatments. Bortezomib blocks the production of nuclear factor-κB (NFκB)-mediated pro-inflammatory cytokines. We report a patient with myeloma who developed a cutaneous leucoclastic vasculitis (LV) after bortezomib treatment. The patient with LV exhibited a marked increase in serum levels of IL-6, TNF-α, and C-reactive protein (CRP). Bortezomib administration may enhance the release of pro-inflammatory cytokines, which might play a role in bortezomib-induced cutaneous LV.

AB - The proteasome inhibitor, bortezomib, has anti-myeloma activity even in myeloma cells refractory to multiple prior treatments. Bortezomib blocks the production of nuclear factor-κB (NFκB)-mediated pro-inflammatory cytokines. We report a patient with myeloma who developed a cutaneous leucoclastic vasculitis (LV) after bortezomib treatment. The patient with LV exhibited a marked increase in serum levels of IL-6, TNF-α, and C-reactive protein (CRP). Bortezomib administration may enhance the release of pro-inflammatory cytokines, which might play a role in bortezomib-induced cutaneous LV.

KW - Bortezomib

KW - IL-6

KW - Leucolcastic vasculitis

KW - Multiple myeloma

KW - TNF-α

UR - https://www.scopus.com/pages/publications/33645071066

U2 - 10.1111/j.0902-4441.2005.t01-1-EJH2437.x

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JF - European Journal of Haematology

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ER -

Cutaneous leucoclastic vasculitis (LV) following bortezomib therapy in a myeloma patient; Association with pro-inflammatory cytokines

Abstract

Keywords

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