Customized valorization of waste streams by Pseudomonas putida: State-of-the-art, challenges, and future trends

Jina Son, Seo Hyun Lim, Yu Jin Kim, Hye Jin Lim, Ji Yeon Lee, Seona Jeong, Chulhwan Park, Si Jae Park

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Preventing catastrophic climate events warrants prompt action to delay global warming, which threatens health and food security. In this context, waste management using engineered microbes has emerged as a long-term eco-friendly solution for addressing the global climate crisis and transitioning to clean energy. Notably, Pseudomonas putida can valorize industry-derived synthetic wastes including plastics, oils, food, and agricultural waste into products of interest, and it has been extensively explored for establishing a fully circular bioeconomy through the conversion of waste into bio-based products, including platform chemicals (e.g., cis,cis-muconic and adipic acid) and biopolymers (e.g., medium-chain length polyhydroxyalkanoate). However, the efficiency of waste pretreatment technologies, capability of microbial cell factories, and practicability of synthetic biology tools remain low, posing a challenge to the industrial application of P. putida. The present review discusses the state-of-the-art, challenges, and future prospects for divergent biosynthesis of versatile products from waste-derived feedstocks using P. putida.

Original languageEnglish
Article number128607
JournalBioresource Technology
StatePublished - Mar 2023

Bibliographical note

Funding Information:
This work is supported by the Development of synthetic microbial platform systems for one step-one pot synthesis of next-generation biodegradable biopolymers (NRF-2022M3J4A1053696) from National Research Foundation (NRF) supported by the Korean Ministry of Science and ICT (MSIT) and R&D Program of MOTIE/KEIT (20018072).

Publisher Copyright:
© 2023


  • Adipic acid
  • Cis,cis-Muconic acid
  • Mcl-PHA
  • Pseudomonas putida
  • Waste management


Dive into the research topics of 'Customized valorization of waste streams by Pseudomonas putida: State-of-the-art, challenges, and future trends'. Together they form a unique fingerprint.

Cite this