Current status of pediatric umbilical cord blood transplantation in Korea: A multicenter retrospective analysis of 236 cases

Keon Hee Yoo, Soo Hyun Lee, Ki Woong Sung, Hong Hoe Koo, Nak Gyun Chung, Bin Cho, Hack Ki Kim, Hyoung Jin Kang, Hee Young Shin, Hyo Seop Ahn, Hee Jo Baek, Dong Kyun Han, Hoon Kook, Tai Ju Hwang, Sun Young Kim, Young Ho Lee, Jeong Ok Hah, Ho Joon Im, Jong Jin Seo, Sang Kyu ParkHyun Joo Jung, Jun Eun Park, Yeon Jung Lim, Seong Shik Park, Young Tak Lim, Eun Sun Yoo, Kyung Ha Ryu, Hyeon Jin Park, Byung Kiu Park

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23 Scopus citations


We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that the sources of the grafts were mostly unrelated donors (n = 226; 95.8%), only the results of unrelated UCBT were included for all statistics. The most frequent primary disease was acute leukemia (n = 167). In total, 91.7% of recipients were seropositive for cytomegalovirus (CMV). The median doses of nucleated cells and CD34+ cells were 4.84 × 107/kg and 2.00 × 105/kg, respectively. The median times to neutrophil (>0.5 × 109/L) and platelet recovery (>20 × 109/L) were 18 and 45 days, respectively. Grade 2-4 acute graft-versus-host-disease (GVHD) and chronic GVHD developed in 41.1 and 36.1% of cases, respectively. Forty-five patients developed CMV disease. The 5-year overall and event-free survival were 47.5 and 36.9%, respectively. Multivariate analysis revealed that adverse factors for survival of the whole cohort were total body irradiation-based conditioning (P = 0.007), salvage transplant (P = 0.001), failure to achieve early complete chimerism (P < 0.0005), and CMV disease (P = 0.001). The outcomes of the single- and double-unit UCBT (n = 64) were similar, while double-unit recipients were heavier (P < 0.0005) and older (P < 0.0005). We conclude that double-unit UCBT is a reasonable option for older or heavier children and that the thorough surveillance of CMV infection and the development of an effective CMV therapeutic strategy may be especially important for Korean children, whose CMV seroprevalence exceeds 90%.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalAmerican Journal of Hematology
Issue number1
StatePublished - Jan 2011


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