Current smoking status as a predictor of cerebral infarction in men: A retrospective cohort study in South Korea

Sang Min Lee, Chang Mo Oh, Min Ho Kim, Eunhee Ha, Minha Hong, Jae Hong Ryoo

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2 Scopus citations


We examined the relationship between duration (pack-year) of smoking and the risk of developing cerebral infarction in Korean men. Retrospective cohort study. National Health Insurance Service-National Sample Cohort in Korea. Of 125 743 male participants from the National Health Insurance System undergoing medical health check-up in 2009, 114 377 were included in the final analysis. Development of cerebral infarction according to smoking duration after adjusting for age, body mass index, systolic blood pressure, fasting blood glucose, total cholesterol, γ-glutamyltransferase, estimated glomerular filtration rate, alcohol intake and physical activity. During 495 827.3 person-years of follow-up, 1450 incident cases of cerebral infarction developed between 2009 and 2013. The multivariate adjusted HRs (95% CI) for cerebral infarction between groups 2, 3 and 4 by duration of smoking were 1.02 (0.88 to 1.19), 1.36 (1.19 to 1.56) and 1.49 (1.28 to 1.74), respectively. In our secondary analysis by smoking status, the HR (95% CI) of former smokers showed a significant relationship in the unadjusted model but did not show statistically significant associations in the multivariate adjusted model. The HR (95% CI) of current smokers showed significant relationship in both the unadjusted and multivariate adjusted models (p for trend <0.001). The study indicates that the prolonged duration of smoking (pack-year) increases the risk of cerebral infarction. Current smoking poses a higher risk for the development of cerebral infraction than former smoking among Korean men, indicating that current smoking cessation would be more protective.

Original languageEnglish
Article numbere042317
JournalBMJ Open
Issue number4
StatePublished - 14 Apr 2021

Bibliographical note

Funding Information:
Funding This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (NRF-2019R1F1A1060615).

Publisher Copyright:
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.


  • public health
  • stroke
  • substance misuse


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