Cupric superoxo-mediated intermolecular C-H activation chemistry

Ryan L. Peterson; Richard A. Himes; Hiroaki Kotani; Tomoyoshi Suenobu; Li Tian; Maxime A. Siegler; Edward I. Solomon; Shunichi Fukuzumi; Kenneth D. Karlin

doi:10.1021/ja110466q

Cupric superoxo-mediated intermolecular C-H activation chemistry

Ryan L. Peterson
, Richard A. Himes
, Hiroaki Kotani
, Tomoyoshi Suenobu
, Li Tian
, Maxime A. Siegler
, Edward I. Solomon
, Shunichi Fukuzumi
, Kenneth D. Karlin

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

152 Scopus citations

Abstract

The new cupric superoxo complex [LCu ^II(O ₂ ^-)] ⁺, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.

Original language	English
Pages (from-to)	1702-1705
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	6
DOIs	https://doi.org/10.1021/ja110466q
State	Published - 16 Feb 2011

Access to Document

10.1021/ja110466q

Cite this

@article{d0ecf9c2faeb46c3908653d11f3289ba,

title = "Cupric superoxo-mediated intermolecular C-H activation chemistry",

abstract = "The new cupric superoxo complex [LCu II(O 2 -)] +, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.",

author = "Peterson, \{Ryan L.\} and Himes, \{Richard A.\} and Hiroaki Kotani and Tomoyoshi Suenobu and Li Tian and Siegler, \{Maxime A.\} and Solomon, \{Edward I.\} and Shunichi Fukuzumi and Karlin, \{Kenneth D.\}",

year = "2011",

month = feb,

day = "16",

doi = "10.1021/ja110466q",

language = "English",

volume = "133",

pages = "1702--1705",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Cupric superoxo-mediated intermolecular C-H activation chemistry

AU - Peterson, Ryan L.

AU - Himes, Richard A.

AU - Kotani, Hiroaki

AU - Suenobu, Tomoyoshi

AU - Tian, Li

AU - Siegler, Maxime A.

AU - Solomon, Edward I.

AU - Fukuzumi, Shunichi

AU - Karlin, Kenneth D.

PY - 2011/2/16

Y1 - 2011/2/16

N2 - The new cupric superoxo complex [LCu II(O 2 -)] +, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.

AB - The new cupric superoxo complex [LCu II(O 2 -)] +, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.

UR - https://www.scopus.com/pages/publications/79951545016

U2 - 10.1021/ja110466q

DO - 10.1021/ja110466q

M3 - Article

C2 - 21265534

AN - SCOPUS:79951545016

SN - 0002-7863

VL - 133

SP - 1702

EP - 1705

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 6

ER -

Cupric superoxo-mediated intermolecular C-H activation chemistry

Abstract

Access to Document

Fingerprint

Cite this