Cupric superoxo-mediated intermolecular C-H activation chemistry

Ryan L. Peterson; Richard A. Himes; Hiroaki Kotani; Tomoyoshi Suenobu; Li Tian; Maxime A. Siegler; Edward I. Solomon; Shunichi Fukuzumi; Kenneth D. Karlin

doi:10.1021/ja110466q

Cupric superoxo-mediated intermolecular C-H activation chemistry

Ryan L. Peterson, Richard A. Himes, Hiroaki Kotani, Tomoyoshi Suenobu, Li Tian, Maxime A. Siegler, Edward I. Solomon, Shunichi Fukuzumi, Kenneth D. Karlin

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

The new cupric superoxo complex [LCu ^II(O ₂ ^-)] ⁺, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.

Original language	English
Pages (from-to)	1702-1705
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	6
DOIs	https://doi.org/10.1021/ja110466q
State	Published - 16 Feb 2011

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abstract = "The new cupric superoxo complex [LCu II(O 2 -)] +, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.",

author = "Peterson, {Ryan L.} and Himes, {Richard A.} and Hiroaki Kotani and Tomoyoshi Suenobu and Li Tian and Siegler, {Maxime A.} and Solomon, {Edward I.} and Shunichi Fukuzumi and Karlin, {Kenneth D.}",

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T1 - Cupric superoxo-mediated intermolecular C-H activation chemistry

AU - Peterson, Ryan L.

AU - Himes, Richard A.

AU - Kotani, Hiroaki

AU - Suenobu, Tomoyoshi

AU - Tian, Li

AU - Siegler, Maxime A.

AU - Solomon, Edward I.

AU - Fukuzumi, Shunichi

AU - Karlin, Kenneth D.

PY - 2011/2/16

Y1 - 2011/2/16

N2 - The new cupric superoxo complex [LCu II(O 2 -)] +, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.

AB - The new cupric superoxo complex [LCu II(O 2 -)] +, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.

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U2 - 10.1021/ja110466q

DO - 10.1021/ja110466q

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AN - SCOPUS:79951545016

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SP - 1702

EP - 1705

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 6

ER -

Cupric superoxo-mediated intermolecular C-H activation chemistry

Abstract

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