Cupric superoxo-mediated intermolecular C-H activation chemistry

Ryan L. Peterson, Richard A. Himes, Hiroaki Kotani, Tomoyoshi Suenobu, Li Tian, Maxime A. Siegler, Edward I. Solomon, Shunichi Fukuzumi, Kenneth D. Karlin

Research output: Contribution to journalArticlepeer-review

140 Scopus citations

Abstract

The new cupric superoxo complex [LCu II(O 2 -)] +, which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.

Original languageEnglish
Pages (from-to)1702-1705
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number6
DOIs
StatePublished - 16 Feb 2011

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