Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

Yu Sung Chun, Ju Hyun Kim, Suh Young Choi, Young Ok Ko, Sang Gi Lee

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)2 to afford pyrimidin-4-ones.

Original languageEnglish
Pages (from-to)6358-6361
Number of pages4
JournalOrganic Letters
Volume14
Issue number24
DOIs
StatePublished - 21 Dec 2012

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