Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

Yu Sung Chun; Ju Hyun Kim; Suh Young Choi; Young Ok Ko; Sang Gi Lee

doi:10.1021/ol303153g

Cu(OAc)₂-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

Yu Sung Chun, Ju Hyun Kim, Suh Young Choi, Young Ok Ko, Sang Gi Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)₂ to afford pyrimidin-4-ones.

Original language	English
Pages (from-to)	6358-6361
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	24
DOIs	https://doi.org/10.1021/ol303153g
State	Published - 21 Dec 2012

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title = "Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones",

abstract = "A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)2 to afford pyrimidin-4-ones.",

author = "Chun, {Yu Sung} and Kim, {Ju Hyun} and Choi, {Suh Young} and Ko, {Young Ok} and Lee, {Sang Gi}",

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T1 - Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

AU - Chun, Yu Sung

AU - Kim, Ju Hyun

AU - Choi, Suh Young

AU - Ko, Young Ok

AU - Lee, Sang Gi

PY - 2012/12/21

Y1 - 2012/12/21

N2 - A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)2 to afford pyrimidin-4-ones.

AB - A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)2 to afford pyrimidin-4-ones.

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U2 - 10.1021/ol303153g

DO - 10.1021/ol303153g

M3 - Article

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AN - SCOPUS:84871572694

SN - 1523-7060

VL - 14

SP - 6358

EP - 6361

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

Abstract

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Cu(OAc)₂-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones