Crystal structure of hypothetical protein HP0062 (O24902-HELPY) from helicobacter pylori at 1.65 Å resolution

Sun Bok Jang, Ae Ran Kwon, Woo Sung Son, Sung Jean Park, Bong Jin Lee

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The HP0062 gene encodes a small acidic protein of 86 amino acids with a theoretical pI of 4.6. The crystal structure of hypothetical protein HP0062 from Helicobacter pylori has been determined at 1.65 Å by molecular- replacement method. The crystallographic asymmetric unit contains dimer, in which HP0062 monomer folds into a helix-hairpin-helix structure. The two protomers are primarily held together by extensive hydrophobic interactions in an antiparallel arrangement, forming a four helix bundle. Aromatic residues located at a or g position in the heptad leucine zipper are not major contributor required for HP0062 dimerization but important for the thermostability of this protein.

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalJournal of Biochemistry
Issue number4
StatePublished - Oct 2009

Bibliographical note

Funding Information:
Ministry of Education, Science and Technology (MEST); Innovative Drug Research Center for Metabolic and Inflammatory Disease; 2008 BK21 Project for Medicine, Dentistry and Pharmacy; New Drug Target Discovery (grant number 370C-20070095).


  • Dimerization interface
  • HP0062
  • Helicobacter pylori
  • Helix-hairpin-helix structure
  • Leucine-zipper


Dive into the research topics of 'Crystal structure of hypothetical protein HP0062 (O24902-HELPY) from helicobacter pylori at 1.65 Å resolution'. Together they form a unique fingerprint.

Cite this