Crowding-induced formation and structural alteration of nuclear compartments: Insights from computer simulations

Jun Soo Kim, Igal Szleifer

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

12 Scopus citations

Abstract

Our understanding of the structural and dynamical characteristics of nuclear structures such as chromosomes and nuclear bodies (NBs) has increased significantly in recent days owing to advances in biophysical and biochemical techniques. These techniques include the use of computer simulations, which have provided further physical insights complementary to findings from experiments. In this chapter, we review recent computer simulation studies on the structural alteration of chromosome subcompartments and the formation and maintenance of NBs in the highly crowded cell nucleus. It is found that because of macromolecular crowding, the degree of chromosome compaction changes significantly and the formation of NBs is facilitated. We further discuss the physical consequences of these phenomena, which may be of critical importance in understanding genome processes.

Original languageEnglish
Title of host publicationInternational Review of Cell and Molecular Biology
PublisherElsevier Inc.
Pages73-108
Number of pages36
DOIs
StatePublished - 2014

Publication series

NameInternational Review of Cell and Molecular Biology
Volume307
ISSN (Print)1937-6448

Keywords

  • Chromosome subcompartments
  • Computer simulation
  • Crowding
  • Nuclear bodies
  • Nuclear structures

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