Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTXVv

Tae Hee Lee, Sun Shin Cha, Chang Seop Lee, Joon Haeng Rhee, Hye Ryun Woo, Kyung Min Chung

Research output: Contribution to journalArticlepeer-review


Gram-negative Vibrio species secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross-reactivity and cross-protectivity of mAbs against V. vulnificus RtxA1/MARTXVv was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly, 24RA and 46RA, which map to the cysteine protease domain of V. cholerae MARTXVc, inhibited CPD autocleavage in vitro; this process is involved in V. cholerae pathogenesis. These results generate new insight into the development of broadly protective mAbs and/or vaccines against Vibrio species with MARTX toxins.

Original languageEnglish
Pages (from-to)793-800
Number of pages8
JournalMicrobiology and Immunology
Issue number11
StatePublished - 1 Nov 2016

Bibliographical note

Funding Information:
We thank Mi Hyun Kim and Hyo Seon Park for technical suggestions and experimental assistance. This work was supported by the Basic Science Research Program (NRF-2015R1D1A1A01056671) of the National Research Foundation of Korea, which is funded by the Ministry of Education.

Publisher Copyright:
© 2016 The Societies and John Wiley & Sons Australia, Ltd


  • MARTX toxin
  • Vibrio species
  • cross-protection
  • monoclonal antibody


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