Cross metathesis assisted solid-phase synthesis of glycopeptoids

Sharaf Nawaz Khan, Arim Kim, Robert H. Grubbs, Yong Uk Kwon

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good yields. This systematic solid-phase CM study can provide facile access to the molecular sources of glycopeptidomimetics and postchemical modifications on various molecular scaffolds.

Original languageEnglish
Pages (from-to)2952-2955
Number of pages4
JournalOrganic Letters
Issue number12
StatePublished - 15 Jun 2012


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