Cough in the Elderly Population: Relationships with Multiple Comorbidity

Woo Jung Song, Alyn H. Morice, Min Hye Kim, Seung Eun Lee, Eun Jung Jo, Sang Min Lee, Ji Won Han, Tae Hui Kim, Sae Hoon Kim, Hak Chul Jang, Ki Woong Kim, Sang Heon Cho, Kyung Up Min, Yoon Seok Chang

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Background:The epidemiology of cough in the elderly population has not been studied comprehensively. The present study aimed to investigate the epidemiology of cough in a community elderly population, particularly in relation with their comorbidity.Methods:A cross-sectional analysis was performed using a baseline dataset from the Korean Longitudinal Study on Health and Aging, a community-based elderly population cohort study. Three types of cough (frequent cough, chronic persistent cough, and nocturnal cough) were defined using questionnaires. Comorbidity was examined using a structured questionnaire. Health-related quality of life was assessed using the Short Form 36 questionnaire.Results:The prevalence was 9.3% for frequent cough, 4.6% for chronic persistent cough, and 7.3% for nocturnal cough. In multivariate logistic regression analyses, smoking, asthma and allergic rhinitis were found to be risk factors for cough in the elderly. Interestingly, among comorbidities, constipation and uncontrolled diabetes mellitus (HbA1c ≥ 8%) were also found to have positive associations with elderly cough. In the Short Form 36 scores, chronic persistent cough was independently related to impairment of quality of life, predominantly in the mental component.Conclusions:Cough has a high prevalence and is detrimental to quality of life in the elderly. Associations with smoking, asthma and rhinitis confirmed previous findings in younger populations. Previously unrecognised relationships with constipation and uncontrolled diabetes mellitus suggested the multi-faceted nature of cough in the elderly.

Original languageEnglish
Article numbere78081
JournalPLoS ONE
Issue number10
StatePublished - 21 Oct 2013


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