@article{4122dce5f08f49178593a298ad40aabc,
title = "Correlation study between A3 adenosine receptor binding affinity and anti-renal interstitial fibrosis activity of truncated adenosine derivatives",
abstract = "Truncated 4′-thionucleosides 1–4 and 4′-oxonucleosides 5–8 as potent and selective A3AR antagonists were synthesized from d-mannose and d-erythronic acid γ-lactone, respectively. These nucleosides were evaluated for their anti-fibrotic renoprotective activity in TGF-β1-treated murine proximal tubular (mProx) cells. Their antagonistic activities for A3AR were proportional to their inhibitory activities against TGF-β1-induced collagen I upregulation in mProx cells. This result suggests that the binding affinity of A3AR antagonists is closely correlated with their anti-fibrotic activity. Thus, A3AR antagonists might be novel therapeutic candidates for treating chronic kidney disease.",
keywords = "A adenosine receptor, Antagonist, Binding affinity, Renal fibrosis, Truncated adenosine",
author = "Jinha Yu and Gyudong Kim and Jarhad, {Dnyandev B.} and Lee, {Hyuk Woo} and Jiyoun Lee and Park, {Chong Woo} and Hunjoo Ha and Jeong, {Lak Shin}",
note = "Funding Information: This research was supported by grants from Mid-career Research Program (2016R1A2B3010164) and Basic Science Research Program (2018R1D1A1B07049982) of the National Research Foundation (NRF), Republic of Korea. Funding Information: Acknowledgements This research was supported by grants from Mid-career Research Program (2016R1A2B3010164) and Basic Science Research Program (2018R1D1A1B07049982) of the National Research Foundation (NRF), Republic of Korea. Publisher Copyright: {\textcopyright} 2018, The Pharmaceutical Society of Korea.",
year = "2019",
month = sep,
day = "1",
doi = "10.1007/s12272-018-1079-2",
language = "English",
volume = "42",
pages = "773--779",
journal = "Archives of Pharmacal Research",
issn = "0253-6269",
publisher = "Pharmaceutical Society of Korea",
number = "9",
}