Correlation of breast cancer subtypes, based on estrogen receptor, progesterone receptor, and HER2, with functional imaging parameters from 68Ga-RGD PET/CT and 18F-FDG PET/CT

Hai Jeon Yoon, Keon Wook Kang, In Kook Chun, Nariya Cho, Seock Ah Im, Sunjoo Jeong, Song Lee, Kyeong Cheon Jung, Yun Sang Lee, Jae Min Jeong, Dong Soo Lee, June Key Chung, Woo Kyung Moon

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Purpose: Imaging biomarkers from functional imaging modalities were assessed as potential surrogate markers of disease status. Specifically, in this prospective study, we investigated the relationships between functional imaging parameters and histological prognostic factors and breast cancer subtypes. Methods: In total, 43 patients with large or locally advanced invasive ductal carcinoma (IDC) were analyzed (47.6±7.5 years old). 68Ga- Labeled arginine-glycine-aspartic acid (RGD) and 18F- fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) were performed. The maximum and average standardized uptake values (SUVmax and SUVavg) from RGD PET/CT and SUVmax and SUVavg from FDG PET/CT were the imaging parameters used. For histological prognostic factors, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression was identified using immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH). Four breast cancer subtypes, based on ER/PR and HER2 expression (ER/PR+,Her2-, ER/PR+,Her2+, ER/PR-,Her2+, and ER/PR-,Her2-), were considered. Results: Quantitative FDG PET parameters were significantly higher in the ER-negative group (15.88±8.73 vs 10.48±6.01, p=0.02 for SUV max; 9.40±5.19 vs 5.92±4.09, p=0.02 for SUV avg) and the PR-negative group (8.37±4.94 vs 4.79±3.93, p=0.03 for SUVavg). Quantitative RGD PET parameters were significantly higher in the HER2-positive group (2.42±0.59 vs 2.90±0.75, p=0.04 for SUVmax; 1.60±0.38 vs 1.95±0.53, p=0.04 for SUVavg) and showed a significant positive correlation with the HER2/CEP17 ratio (r=0.38, p=0.03 for SUV max and r=0.46, p<0.01 for SUVavg). FDG PET parameters showed significantly higher values in the ER/PR-,Her2- subgroup versus the ER/PR+,Her2- or ER/PR+,Her2+ subgroups, while RGD PET parameters showed significantly lower values in the ER/PR-,Her2- subgroup versus the other subgroups. There was no correlation between FDG and RGD PET parameters in the overall group. Only the ER/PR-,Her2- subgroup showed a significant positive correlation between FDG and RGD PET parameters (r=0.59, p=0.03 for SUV max). Conclusion: 68Ga-RGD and 18F-FDG PET/CT are promising functional imaging modalities for predicting biomarkers and molecular phenotypes in breast cancer patients.

Original languageEnglish
Pages (from-to)1534-1543
Number of pages10
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume41
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Arginine-glycine-aspartic acid (RGD)
  • Estrogen receptor (ER)
  • Fluorodeoxyglucose (FDG)
  • Human epidermal growth factor receptor 2 (HER2)
  • Positron emission tomography (PET)
  • Progesterone receptor (PR)

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