Corpus callosum differences associated with persistent stuttering in adults

Ai Leen Choo, Shelly Jo Kraft, William Olivero, Nicoline G. Ambrose, Harish Sharma, Soo Eun Chang, Torrey M. Loucks

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Recent studies have implicated anatomical differences in speech-relevant brain regions of adults who stutter (AWS) compared to normally fluent adults (NFA). The present study focused on the region of the corpus callosum (CC) which is involved in interhemispheric processing between the left and right cerebral hemispheres. Two-dimensional segmentation of area and voxel-based morphometry were used to evaluate the corpus callosum. Results revealed that the rostrum and anterior midbody of the CC were larger in AWS than NFA. In addition, the overall callosa area was larger in AWS than NFA. The group comparison of white matter volume showed a cluster of increased white matter volume predominantly encompassing the rostrum across the midline portion in AWS. These results potentially reflect anatomical changes associated with differences in the hemispheric distribution of language processes that have been reported previously in AWS.Learning outcomes: After reading this article, the reader will be able to: (1) summarize research findings on functional and anatomical differences between AWS and NFA; (2) summarize research findings on anatomical anomalies observed in AWS; (3) discuss the possible relationships between functional and anatomical aberrations in AWS; and (4) discuss how the findings of the present study may support results of previous behavioral investigations (e.g. dichotic listening) in AWS.

Original languageEnglish
Pages (from-to)470-477
Number of pages8
JournalJournal of Communication Disorders
Issue number4
StatePublished - Jul 2011

Bibliographical note

Funding Information:
The authors wish to acknowledge the volunteers who participated in this study and Dr. Donald G. Bullock for his help with the statistical analysis. The study was partially supported by an American Speech Language Hearing Foundation New Investigators Research Grant (P.I. Torrey Loucks), an Internal Research Board Grant from the University of Illinois (P.I. Torrey Loucks) and NIH RO1 DC 05201 – Subtypes and Associated Risk Factors in Stuttering (P.I. Nicoline Ambrose).


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