Copper(II)-mof containing glutarate and 4,4-azopyridine and its antifungal activity

Sohyeon Yang, Mayura Veerana, Nannan Yu, Wirinthip Ketya, Gyungsoon Park, Sungjin Kim, Youngmee Kim

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10 Scopus citations


Antifungal activities of MOFs (metal organic frameworks) have been demonstrated in studies, and improvement in efficiency of fungal inactivation is a critical issue in the application of MOFs. In this study, we employed 4,4-azopyridine (AZPY) in the construction of MOF to improve its antifungal activity. Three-dimensional (3D) copper metal organic framework containing glutarate (Glu) and AZPY (Cu(AZPY)-MOF) was synthesized by a solvothermal reaction. Glutarates bridge Cu2 dinuclear units to form two-dimensional (2D) layers, and these layers are connected by AZPY to form a 3D framework. When spores of two fungi, Candida albicans and Aspergillus niger, were treated with Cu(AZPY)-MOF for one day, number of CFU (colony forming unit) was continuously reduced over treated MOF concentrations, and maximum 2.3 and 2.5 log10CFU reductions (approximately 99% reduction) were observed in C. albicans and A. niger, respectively. Small amounts of CuII ions and AZPY released from Cu(AZPY)-MOF were not critical for fungal inactivation. Our results indicate that the level of antifungal activity of Cu(AZPY)-MOF is greater than that of Cu-MOF without AZPY constructed in our previous study, and intercalation of AZPY is able to improve the antifungal activity of Cu(AZPY)-MOF.

Original languageEnglish
Article number260
JournalApplied Sciences (Switzerland)
Issue number1
StatePublished - 1 Jan 2022

Bibliographical note

Funding Information:
Funding: This work was supported by the Basic Science Research Program of the National Research Foundation of Korea, which was funded by the Ministry of Education, Science and Technology (2018R1D1A1B07045327, 2020R1F1A1070942, 2021R1A6A1A03038785).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • 4,4-azopyridine
  • Antifungal activity
  • Glutaric acid
  • Metal-organic frameworks (MOFs)
  • X-ray crystallography


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