Copper-mediated selective cyanation of indoles and 2-phenylpyridines with ammonium iodide and DMF

Jinho Kim, Hyunwoo Kim, Sukbok Chang

Research output: Contribution to journalArticlepeer-review

98 Scopus citations

Abstract

Copper-mediated regioselective cyanation of indoles and 2-phenylpyridines was developed by using ammonium iodide and DMF as the combined source of a cyano unit under "Pd-free" conditions. Mechanistic studies indicate that the reaction of indoles proceeds through a two-step sequence: electrophilic initial iodination and then cyanation. The cyanation has a broad substrate scope, high functional group tolerance, and excellent regioselectivity.

Original languageEnglish
Pages (from-to)3924-3927
Number of pages4
JournalOrganic Letters
Volume14
Issue number15
DOIs
StatePublished - 3 Aug 2012

Fingerprint

Dive into the research topics of 'Copper-mediated selective cyanation of indoles and 2-phenylpyridines with ammonium iodide and DMF'. Together they form a unique fingerprint.

Cite this