A new and mild synthetic approach for the synthesis of N-arylsulfonamides under copper-catalyzed conditions at room temperature has been developed. The reaction employs various tert-butyl N-sulfonylcarbamates and diaryliodonium salts to avoid potential genotoxic impurities. A one-pot coupling/Boc-deprotection sequence is also reported to provide mono N-arylsulfonamides in good to excellent yields.
- Copper catalysis
- Diaryliodonium salts
- Mono N-arylsulfonamides
- Room temperature
- tert-Butyl N-sulfonylcarbamates