Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature

Seo Hee Jung; Dan Bi Sung; Cho Hee Park; Won Suk Kim

doi:10.1021/acs.joc.6b01415

Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature

Seo Hee Jung
, Dan Bi Sung
, Cho Hee Park
, Won Suk Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature.

Original language	English
Pages (from-to)	7717-7724
Number of pages	8
Journal	Journal of Organic Chemistry
Volume	81
Issue number	17
DOIs	https://doi.org/10.1021/acs.joc.6b01415
State	Published - 2 Sep 2016

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© 2016 American Chemical Society.

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abstract = "A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol \% of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23\% to 99\%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99\% yield within 30 min at room temperature.",

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AU - Kim, Won Suk

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AB - A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature.

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Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature

Abstract

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