@article{1eb7c3bbcbca444c9e316e37101f85b3,
title = "Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature",
abstract = "A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature.",
author = "Jung, {Seo Hee} and Sung, {Dan Bi} and Park, {Cho Hee} and Kim, {Won Suk}",
note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) (NRF-015R1A1A1A05001334) and the New & Renewable Energy of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant (No.20133030000210) Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2016",
month = sep,
day = "2",
doi = "10.1021/acs.joc.6b01415",
language = "English",
volume = "81",
pages = "7717--7724",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "17",
}