Abstract
A new and mild synthetic approach for the N-arylation of 2-pyridones with diaryliodonium salts has been developed. Most reactions proceed readily at room temperature in the presence of 10 mol % of copper chloride. As a result, a wide range of N-arylpyridine-2-ones were synthesized in yields of 23% to 99%. With this method, an antifibrotic drug, Pirfenidone, was successfully synthesized in 99% yield within 30 min at room temperature.
Original language | English |
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Pages (from-to) | 7717-7724 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 81 |
Issue number | 17 |
DOIs | |
State | Published - 2 Sep 2016 |
Bibliographical note
Publisher Copyright:© 2016 American Chemical Society.