Cooperative Rh(II)/Pd(0) Dual Catalysis for the Synthesis of Carbo- And Heterocyclic Compounds

Kyu Ree Lee, Yu Lim Lee, Kyu In Choi, Sang Gi Lee

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Dual transition-metal catalysis has been introduced as a robust tool to synthesize a diverse range of organic compounds that cannot to be accessed by traditional single-metal catalysis. In this context, we have recently developed cooperative Rh(II)/Pd(0) dual catalytic systems that have been utilized for the preparation of heterocyclic com-pounds through the reaction between Rh(II)-carbenoid and π-allyl Pd(II)-complex intermediates in either synergistic or tandem relay catalysis. In synergistic Rh(II)/Pd(0) dual catalysis, the two reactive intermediates are generated simultaneously, which then undergo formal [6+3] dipolar cycloaddition to afford medium-sized heterocyclic compounds. On the other hand, tandem relay dual catalysis can be enabled through judicious choice of reaction parameters, which proceed through the in-sertion of Rh(II)-carbenoid into O-H or C-H bonds, followed by Pd(0)- catalyzed allylation to provide allylated benzo-fused cyclic compounds or chiral β-lactam derivatives.

Original languageEnglish
JournalSynthesis (Germany)
StateAccepted/In press - 2021


  • carbocycle
  • dual catalysis
  • heterocycle
  • palladium catalysis
  • rhodium catalysis
  • synergistic catalysis
  • tandem relay catalysis


Dive into the research topics of 'Cooperative Rh(II)/Pd(0) Dual Catalysis for the Synthesis of Carbo- And Heterocyclic Compounds'. Together they form a unique fingerprint.

Cite this