Cooperative Rh(II)/Pd(0) Dual Catalysis for the Synthesis of Carbo- and Heterocyclic Compounds

Kyu Ree Lee, Yu Lim Lee, Kyu In Choi, Sang Gi Lee

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Dual transition-metal catalysis has been introduced as a robust tool to synthesize a diverse range of organic compounds that cannot to be accessed by traditional single-metal catalysis. In this context, we have recently developed cooperative Rh(II)/Pd(0) dual catalytic systems that have been utilized for the preparation of heterocyclic compounds through the reaction between Rh(II)-carbenoid and π-allyl Pd(II)-complex intermediates in either synergistic or tandem relay catalysis. In synergistic Rh(II)/Pd(0) dual catalysis, the two reactive intermediates are generated simultaneously, which then undergo formal [6+3] dipolar cycloaddition to afford medium-sized heterocyclic compounds. On the other hand, tandem relay dual catalysis can be enabled through judicious choice of reaction parameters, which proceed through the insertion of Rh(II)-carbenoid into O H or C H bonds, followed by Pd(0)-catalyzed allylation to provide allylated benzo-fused cyclic compounds or chiral β-lactam derivatives.

Original languageEnglish
Article numberss-2021-z0465-sr
Pages (from-to)555-564
Number of pages10
JournalSynthesis (Germany)
Issue number3
StatePublished - 15 Nov 2021

Bibliographical note

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© 2022 American Institute of Physics Inc.. All rights reserved.


  • carbocycle
  • dual catalysis
  • heterocycle
  • palladium catalysis
  • rhodium catalysis
  • synergistic catalysis
  • tandem relay catalysis


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