Convergent synthesis of a fully lipidated glycosylphosphatidylinositol anchor of Plasmodium falciparum

Xinyu Liu, Yong Uk Kwon, Peter H. Seeberger

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

A highly convergent strategy for the synthesis of fully lipidated GPI anchors of malarial origin is reported. This strategy utilized three orthogonal protecting groups, which can be chemoselectively deprotected and functionalized in the late stage of the synthesis. Rapid access to the target GPIs in a highly efficient manner in sufficient quantities for the biological studies has been achieved.

Original languageEnglish
Pages (from-to)5004-5005
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number14
DOIs
StatePublished - 13 Apr 2005

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