Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Hue Thi My Van; Quynh Manh Le; Kwang Youl Lee; Eung Seok Lee; Youngjoo Kwon; Tae Sung Kim; Thanh Nguyen Le; Suh Hee Lee; Won Jea Cho

doi:10.1016/j.bmcl.2007.08.062

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Hue Thi My Van
, Quynh Manh Le
, Kwang Youl Lee
, Eung Seok Lee
, Youngjoo Kwon
, Tae Sung Kim
, Thanh Nguyen Le
, Suh Hee Lee
, Won Jea Cho

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ⁱbutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l.

Original language	English
Pages (from-to)	5763-5767
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2007.08.062
State	Published - 1 Nov 2007

Bibliographical note

Funding Information:
This work was supported by Korea Research Foundation Grant (KRF-2004-013-E00031).

Keywords

Antitumor agents
Cytotoxicity
Docking study
Indenoisoquinoline
Synthesis
Topoisomerase 1

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10.1016/j.bmcl.2007.08.062

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Van, H. T. M., Le, Q. M., Lee, K. Y., Lee, E. S., Kwon, Y., Kim, T. S., Le, T. N., Lee, S. H., & Cho, W. J. (2007). Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex. Bioorganic and Medicinal Chemistry Letters, 17(21), 5763-5767. https://doi.org/10.1016/j.bmcl.2007.08.062

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title = "Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex",

abstract = "11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l.",

keywords = "Antitumor agents, Cytotoxicity, Docking study, Indenoisoquinoline, Synthesis, Topoisomerase 1",

author = "Van, \{Hue Thi My\} and Le, \{Quynh Manh\} and Lee, \{Kwang Youl\} and Lee, \{Eung Seok\} and Youngjoo Kwon and Kim, \{Tae Sung\} and Le, \{Thanh Nguyen\} and Lee, \{Suh Hee\} and Cho, \{Won Jea\}",

note = "Funding Information: This work was supported by Korea Research Foundation Grant (KRF-2004-013-E00031). ",

year = "2007",

month = nov,

day = "1",

doi = "10.1016/j.bmcl.2007.08.062",

language = "English",

volume = "17",

pages = "5763--5767",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

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}

Van, HTM, Le, QM, Lee, KY, Lee, ES, Kwon, Y, Kim, TS, Le, TN, Lee, SH & Cho, WJ 2007, 'Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex', Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 21, pp. 5763-5767. https://doi.org/10.1016/j.bmcl.2007.08.062

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex. / Van, Hue Thi My; Le, Quynh Manh; Lee, Kwang Youl et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 21, 01.11.2007, p. 5763-5767.

Research output: Contribution to journal › Article › peer-review

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T1 - Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

AU - Van, Hue Thi My

AU - Le, Quynh Manh

AU - Lee, Kwang Youl

AU - Lee, Eung Seok

AU - Kwon, Youngjoo

AU - Kim, Tae Sung

AU - Le, Thanh Nguyen

AU - Lee, Suh Hee

AU - Cho, Won Jea

N1 - Funding Information: This work was supported by Korea Research Foundation Grant (KRF-2004-013-E00031).

PY - 2007/11/1

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KW - Antitumor agents

KW - Cytotoxicity

KW - Docking study

KW - Indenoisoquinoline

KW - Synthesis

KW - Topoisomerase 1

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VL - 17

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EP - 5767

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 21

ER -

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Abstract

Bibliographical note

Keywords

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