Abstract
A simple synthesis, involving a key coupling reaction, and the biological activity of the title compounds 16 and 17 are described. The key fragments are the amine·HCl salt 6 and the acids 9 and 13, which were smoothly coupled by using ethyl(dimethylaminopropyl)carbodiimide (EDCI) and 1- hydroxybenzotriazole (HOBt) in high yield. We have found that the in vitro growth inhibitory potency of the new compounds 16 and 17 exhibits good histone deacetylase (HDAC) activity.
Original language | English |
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Pages (from-to) | 1300-1304 |
Number of pages | 5 |
Journal | Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences |
Volume | 63 |
Issue number | 11 |
DOIs | |
State | Published - 2008 |
Bibliographical note
Funding Information:This work has been supported by the KOSEF Brain Neurobiology Grant (2007), by the Ewha Global Challenge (BK21) grant, and in part by Cooperative Agreement Number 1-U01 C1000211 from the Centers for Disease Control and Prevention (M. A. A.).
Keywords
- 4-Oxopiperidine-1-carboxylate
- 4-Oxopyrrolidine-1-carboxylate
- Acetylation
- Coupling synthesis