Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditions

Soosung Kang, Minh Thanh La, Hee Kwon Kim

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A facile method for the direct synthesis of amides from aldehydes is described. Amide bonds were synthesized by an oxidative amidation in the presence of dibromoisocyanuric acid (DBI). Treatment of aromatic and aliphatic aldehydes with dibromoisocyanuric acid generated acyl bromide intermediates, which were employed to react with a variety of secondary and primary amines to give amides. Through this reaction method, various amides were synthesized directly from aldehydes under mild conditions in high yields and short times. This facile and efficient procedure provides potential strategy for the direct synthesis of amides from aldehydes.

Original languageEnglish
Pages (from-to)3541-3546
Number of pages6
JournalTetrahedron Letters
Volume59
Issue number39
DOIs
StatePublished - 26 Sep 2018

Keywords

  • Acyl bromide
  • Aldehydes
  • Amidation
  • Dibromoisocyanuric acid

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