Abstract
Platelet-derived growth factor-BB (PDGF-BB) was incorporated into porous poly (L-lactide) (PLLA) membranes with an aim of improving early bone healing in guided tissue regeneration (GTR) therapy. Porous PDGF-BB loaded membranes were fabricated by coating PDGF-BB-dissolved PLLA methylene chloride-ethyl acetate solutions on polyglycolic acid (PGA) meshes. Release kinetics of PDGF-BB, biologic activity, degradability and guided tissue regenerative potentials of the membranes were investigated. Release of PDGF-BB could be controlled by adding bovine serum albumin that may provide porous diffusion channels for PDGF-BB release and by varying initial loading content of PDGF- BB. Biologic activity of PDGF-BB in the membranes was ascertained by fibroblast chemotaxis. PDGF-BB loaded membranes maintained proper degradation property for periodontal application. PDGF-BB loaded membrane markedly increased new bone formation in rat calvarial defects, and completed bony reunion after 2 weeks of implantation period. These results suggested that PDGF-BB loaded PLLA membrane might potentially enhance guided tissue regenerative efficacy.
| Original language | English |
|---|---|
| Pages (from-to) | 201-211 |
| Number of pages | 11 |
| Journal | Journal of Controlled Release |
| Volume | 51 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - 12 Feb 1998 |
Bibliographical note
Funding Information:The authors are thankful to Sam Yang Group R and D Center for providing materials. This work was supported by the grant of Korea Science and Engineering Foundation (KOSEF) #94-0403-05-02-3, Korea.
Keywords
- Controlled release
- Guided tissue regeneration
- Platelet-derived growth factor
- Poly (L-lactide) membrane