Controlled release of platelet-derived growth factor from porous poly(L- lactide) membranes for guided tissue regeneration

Yoon Jeong Park, Young Ku, Chong Pyoung Chung, Seung Jin Lee

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

Platelet-derived growth factor-BB (PDGF-BB) was incorporated into porous poly (L-lactide) (PLLA) membranes with an aim of improving early bone healing in guided tissue regeneration (GTR) therapy. Porous PDGF-BB loaded membranes were fabricated by coating PDGF-BB-dissolved PLLA methylene chloride-ethyl acetate solutions on polyglycolic acid (PGA) meshes. Release kinetics of PDGF-BB, biologic activity, degradability and guided tissue regenerative potentials of the membranes were investigated. Release of PDGF-BB could be controlled by adding bovine serum albumin that may provide porous diffusion channels for PDGF-BB release and by varying initial loading content of PDGF- BB. Biologic activity of PDGF-BB in the membranes was ascertained by fibroblast chemotaxis. PDGF-BB loaded membranes maintained proper degradation property for periodontal application. PDGF-BB loaded membrane markedly increased new bone formation in rat calvarial defects, and completed bony reunion after 2 weeks of implantation period. These results suggested that PDGF-BB loaded PLLA membrane might potentially enhance guided tissue regenerative efficacy.

Original languageEnglish
Pages (from-to)201-211
Number of pages11
JournalJournal of Controlled Release
Volume51
Issue number2-3
DOIs
StatePublished - 12 Feb 1998

Keywords

  • Controlled release
  • Guided tissue regeneration
  • Platelet-derived growth factor
  • Poly (L-lactide) membrane

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