Controlled release of platelet-derived growth factor-BB from chondroitin sulfate-chitosan sponge for guided bone regeneration

Yoon Jeong Park, Yong Moo Lee, Ju Yeon Lee, Yang Jo Seol, Chong Pyoung Chung, Seung Jin Lee

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

Platelet-derived growth factor-BB (PDGF-BB) releasing porous chondroitin-4-sulfate (CS)-chitosan sponge was designed with an aim of controlling growth factor delivery in order to improve bone formation. Porous CS-chitosan sponge was fabricated by freeze drying and crosslinking aqueous CS-chitosan solution. PDGF-BB was incorporated into the CS-chitosan sponge by soaking CS-chitosan sponge into the PDGF-BB solution. CS-chitosan sponge retained a porous structure with a 150-200-μm pore diameter that was suitable for cellular migration and osteoid ingrowth. Release rate of PDGF-BB could be controlled by varying the composition of CS in the sponge or initial loading content of PDGF-BB. CS-chitosan sponge induced increased osteoblast migration and proliferation as compared with chitosan sponge alone. Furthermore, the release of PDGF-BB from CS-chitosan sponge significantly enhanced osteoblast proliferation. These results suggest that PDGF-BB-releasing CS-chitosan sponge may be beneficial to enhance bone cell adaptation and regenerative potential when applied in wound sites. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)385-394
Number of pages10
JournalJournal of Controlled Release
Volume67
Issue number2-3
DOIs
StatePublished - 3 Jul 2000

Keywords

  • Bone regeneration
  • Chondroitin sulfate-chitosan sponge
  • Controlled release
  • Platelet-derived growth factor-BB

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