Controlled ovarian hyperstimulation for fertility preservation in women with breast cancer: Practical issues

So Yun Park, Kyungah Jeong, Eun Hye Cho, Hye Won Chung

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

In Korean women, a westernized lifestyle is associated with an increased risk of breast cancer. Fertility preservation has become an increasingly important issue for women with breast cancer, in accordance with substantial improvements in survival rate after cancer treatment. The methods of controlled ovarian hyperstimulation (COH) for fertility preservation in breast cancer patients have been modified to include aro- matase inhibitors to reduce the potential harm associated with increased estradiol levels. Random-start COH and dual ovarian stimulation are feasible options to reduce the total duration of fertility preservation treatment and to efficiently collect oocytes or embryos. Using a go-nadotropin-releasing hormone agonist as a trigger may improve cycle outcomes in breast cancer patients undergoing COH for fertility pres-ervation. In young breast cancer patients with BRCA mutations, especially BRCA1 mutations, the possibility of diminished ovarian reserve may be considered, although further studies are necessary. Herein, we review the current literature on the practical issues surrounding COH for fertility preservation in women with breast cancer.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalClinical and Experimental Reproductive Medicine
Volume48
Issue number1
DOIs
StatePublished - 2021

Bibliographical note

Publisher Copyright:
©2021.The Korean Society For Reproductive Medicine.All rights reserved.

Keywords

  • Breast neoplasms
  • Fertility preservation
  • Ovarian hyperstimulation

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