Control of redox reactivity of flavin and pterin coenzymes by metal ion coordination and hydrogen bonding

Shunichi Fukuzumi, Takahiko Kojima

Research output: Contribution to journalShort surveypeer-review

46 Scopus citations

Abstract

The electron-transfer activities of flavin and pterin coenzymes can be fine-tuned by coordination of metal ions, protonation and hydrogen bonding. Formation of hydrogen bonds with a hydrogen-bond receptor in metal-flavin complexes is made possible depending on the type of coordination bond that can leave the hydrogen-bonding sites. The electron-transfer catalytic functions of flavin and pterin coenzymes are described by showing a number of examples of both thermal and photochemical redox reactions, which proceed by controlling the electron-transfer reactivity of coenzymes with metal ion binding, protonation and hydrogen bonding.

Original languageEnglish
Pages (from-to)321-333
Number of pages13
JournalJournal of Biological Inorganic Chemistry
Volume13
Issue number3
DOIs
StatePublished - Mar 2008

Bibliographical note

Funding Information:
Acknowledgments The authors gratefully acknowledge the contributions of their collaborators and coworkers mentioned in the references. The authors acknowledge continuous support of their study by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

Keywords

  • Cofactor
  • Electron transfer
  • Flavin
  • Photoreduction
  • Pterin

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