Construction of a bioactive copper-based metal organic framework-embedded dual-crosslinked alginate hydrogel for antimicrobial applications

Kihak Gwon, Seonhwa Lee, Youngmee Kim, Jun Choi, Sujin Kim, Sung Jin Kim, Hye Jin Hong, Youngmin Hwang, Munemasa Mori, Do Nam Lee

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Metal-organic frameworks (MOFs) containing bioactive metals have the potential to exhibit antimicrobial activity by releasing metal ions or ligands through the cleavage of metal-ligand bonds. Recently, copper-based MOFs (Cu-MOFs) with sustained release capability, porosity, and structural flexibility have shown promising antimicrobial properties. However, for clinical use, the controlled release of Cu2+ over an extended time period is crucial to prevent toxicity. In this study, we developed an alginate-based antimicrobial scaffold and encapsulated MOFs within a dual-crosslinked alginate polymer network. We synthesized Cu-MOFs containing glutarate (Glu) and 4,4′-azopyridine (AZPY) (Cu(AZPY)-MOF) and encapsulated them in an alginate-based hydrogel through a combination of visible light-induced photo and calcium ion-induced chemical crosslinking processes. We confirmed Cu(AZPY)-MOF synthesis using scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, and thermogravimetric analysis. This antimicrobial hydrogel demonstrated excellent antibacterial and antifungal properties against two bacterial strains (MRSA and S. mutans, with >99.9 % antibacterial rate) and one fungal strain (C. albicans, with >78.7 % antifungal rate) as well as negligible cytotoxicity towards mouse embryonic fibroblasts, making it a promising candidate for various tissue engineering applications in biomedical fields.

Original languageEnglish
Article number124840
JournalInternational Journal of Biological Macromolecules
Volume242
DOIs
StatePublished - 1 Jul 2023

Bibliographical note

Publisher Copyright:
© 2023

Keywords

  • Antimicrobial agent
  • Dual-crosslinking hydrogel
  • Metal organic framework

Fingerprint

Dive into the research topics of 'Construction of a bioactive copper-based metal organic framework-embedded dual-crosslinked alginate hydrogel for antimicrobial applications'. Together they form a unique fingerprint.

Cite this