Consolidated microbial production of four-, five-, and six-carbon organic acids from crop residues: Current status and perspectives

Jina Son, Jeong Chan Joo, Kei Anne Baritugo, Seona Jeong, Ji Yeon Lee, Hye Jin Lim, Seo Hyun Lim, Jee In Yoo, Si Jae Park

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The production of platform organic acids has been heavily dependent on petroleum-based industries. However, petrochemical-based industries that cannot guarantee a virtuous cycle of carbons released during various processes are now facing obsolescence because of the depletion of finite fossil fuel reserves and associated environmental pollutions. Thus, the transition into a circular economy in terms of the carbon footprint has been evaluated with the development of efficient microbial cell factories using renewable feedstocks. Herein, the recent progress on bio-based production of organic acids with four-, five-, and six-carbon backbones, including butyric acid and 3-hydroxybutyric acid (C4), 5-aminolevulinic acid and citramalic acid (C5), and hexanoic acid (C6), is discussed. Then, the current research on the production of C4–C6 organic acids is illustrated to suggest future directions for developing crop-residue based consolidated bioprocessing of C4-C6 organic acids using host strains with tailor-made capabilities.

Original languageEnglish
Article number127001
JournalBioresource Technology
StatePublished - May 2022

Bibliographical note

Funding Information:
This work was supported by the Bio & Medical Technology Development Program from the Ministry of Science and ICT (MSIT) through the NRF of Korea (NRF-2018M3A9H3020459 and NRF-2020M3A9I5037888) and Mid-Career Researcher Program of NRF funded by the MSIT (NRF-2021R1A2C2011669). Jina Son appreciates the support by the Ewha Womans University scholarship of 2021.

Publisher Copyright:
© 2022 Elsevier Ltd


  • Consolidated bioprocessing
  • Crop residues
  • Metabolic engineering
  • Microbial cell factory
  • Organic acids


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