Consolidated microbial production of four-, five-, and six-carbon organic acids from crop residues: Current status and perspectives

Jina Son, Jeong Chan Joo, Kei Anne Baritugo, Seona Jeong, Ji Yeon Lee, Hye Jin Lim, Seo Hyun Lim, Jee In Yoo, Si Jae Park

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The production of platform organic acids has been heavily dependent on petroleum-based industries. However, petrochemical-based industries that cannot guarantee a virtuous cycle of carbons released during various processes are now facing obsolescence because of the depletion of finite fossil fuel reserves and associated environmental pollutions. Thus, the transition into a circular economy in terms of the carbon footprint has been evaluated with the development of efficient microbial cell factories using renewable feedstocks. Herein, the recent progress on bio-based production of organic acids with four-, five-, and six-carbon backbones, including butyric acid and 3-hydroxybutyric acid (C4), 5-aminolevulinic acid and citramalic acid (C5), and hexanoic acid (C6), is discussed. Then, the current research on the production of C4–C6 organic acids is illustrated to suggest future directions for developing crop-residue based consolidated bioprocessing of C4-C6 organic acids using host strains with tailor-made capabilities.

Original languageEnglish
Article number127001
JournalBioresource Technology
Volume351
DOIs
StatePublished - May 2022

Keywords

  • Consolidated bioprocessing
  • Crop residues
  • Metabolic engineering
  • Microbial cell factory
  • Organic acids

Fingerprint

Dive into the research topics of 'Consolidated microbial production of four-, five-, and six-carbon organic acids from crop residues: Current status and perspectives'. Together they form a unique fingerprint.

Cite this