Conformation of cyclosporin A in polar solvents

SOO YOUNG KO, CLAUDIO DALVIT

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68 Scopus citations

Abstract

A major conformation of cyclosporin A in methanol and in aqueous methanol was revealed by some simple NMR experiments. Thus, a stepwise transition of cyclosporin A conformation from 100% CDCl3 to 100% CD3OD was followed by 1H NMR, which showed that the chloroform conformation of cyclosporin A was still the major one in methanol. Employing the same technique, it was also shown that the chloroform conformation of cyclosporin A was one of the major conformations in 50% aqueous methanol. This may be the first experimental determination of a major conformation of cyclosporin A in polar solvents.

Original languageEnglish
Pages (from-to)380-382
Number of pages3
JournalInternational Journal of Peptide and Protein Research
Volume40
Issue number5
DOIs
StatePublished - Nov 1992

Keywords

  • conformation
  • cyclosporin A
  • NMR spectroscopy
  • polar solvents

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