Computed tomography findings in ABO-incompatible living donor liver transplantation recipients with biliary strictures

Sang Hyun Choi, Kyoung Won Kim, So Yeon Kim, Jin Sil Kim, Jae Hyun Kwon, Gi Won Song, Sung Gyu Lee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objectives To evaluate CT findings of biliary strictures in ABO-incompatible living donor liver transplantation (LDLT) recipients, with emphasis on associated 1-month post-transplantation CT findings, and evaluate clinical outcomes. Methods Of 351 ABO-incompatible recipients, we retrospectively evaluated CT scans in 65 recipients with biliary stricture. The biliary strictures on CT scans were classified as type A (perihilar) and type B (diffuse). Precedent CTabnormality patterns and the presence of a periportal halo sign at 1-month post-transplantation were evaluated. For each patient, clinical outcomes were evaluated. Results Of 65 ABO-incompatible recipients with biliary strictures, 36.9% had type B strictures. Compared with biliary strictures at diagnosis, similar CT abnormality patterns were observed for 84.4% in type A and 86.4% in type B strictures at 1-month post-transplantation. Complex periportal halo signs on the 1-month post-transplantation CT were more frequently noted for type B than type A strictures (86.4% vs. 3.1%, P < 0.001). Progressive clinical outcomes were more frequently observed for type B than type A strictures (79.2% vs. 26.8%, P < 0.001), with a significantly shorter graft survival time (46.4 months vs. 90.8 months, P < 0.001). Conclusion CT abnormality patterns and complex periportal halo signs on 1-month post-transplantation CT may be clinically useful for managing biliary strictures in ABO-incompatible LDLT recipients.

Original languageEnglish
Pages (from-to)2572-2581
Number of pages10
JournalEuropean Radiology
Volume28
Issue number6
DOIs
StatePublished - 2 Jan 2018

Keywords

  • Bile ducts
  • Blood group incompatibility
  • Computed tomography
  • Liver transplantation
  • Outcome

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