Compositional analysis of walnut lipid extracts and properties as an anti-cancer stem cell regulator via suppression of the self-renewal capacity

Jooyeon Chung, Yoo Sun Kim, Jisoo Lee, Jae Hwan Lee, Sang Woon Choi, Yuri Kim

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Colon cancer is a leading cause of cancer-related deaths worldwide. Effects of walnut (Juglans regia L.) lipid extracts (WLEs) on the self-renewal capacity of cancer stem cells (CSCs) in colon cancer were investigated. The dominant component of WLEs was α-linoleic acid (64.6%), followed by α-linolenic acid (14.6%), and oleic acid (12.6%). A higher concentration of γ-tocopherol (37.1%) was also present than of α-tocopherol (0.6%). CD133+CD44+CSCs treated with WLEs showed inhibition of colony formation and sphere formation, indicating a decrease in the self-renewal capacity. Treatment with WLEs also resulted in down-regulation of protein levels, including Notch1, phospho-GSK3β (p-GSK3β), and β-catenin, which are associated with CSCs and the self-renewing capacity. WLEs rich in essential fatty acids and γ-tocopherol can exert therapeutic actions on colon cancer via targeting of CSCs.

Original languageEnglish
Pages (from-to)623-629
Number of pages7
JournalFood Science and Biotechnology
Volume25
Issue number2
DOIs
StatePublished - 1 Apr 2016

Bibliographical note

Publisher Copyright:
© 2016, The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.

Keywords

  • cancer stem cell
  • colon cancer
  • self-renewal capacity
  • walnut lipid extract

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